CELLONIC BOOSTER EFFECT

• Healing effect on skin wounds
  And regenerative effect on skin tissue

  Stem cell culture medium is very effective for migration and proliferation of fibroblast, and wounds closed up completely when Cellonic Booster was processed on dermal fibroblast(HDF-neonatal). For cell proliferation effect, it was identified that it is more effective for epidermal keratinocyte than EGF(Epidermal Growth Factor).

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• Promotion effect on collagen and
  hyaluronic acid expression

  Showed promotion effect of hyaluronic acid and collagen biosynthesis effect, and stem cell culture medium induced higher expression of hyaluronic acid and collagen than TGF-β, the positive control group when 12/24/36/48 hours of production of hyaluronic acid of negative control(unprocessed control group), positive control(TGF-β treatment group: growth factor that promotes expression of hyaluronic acid and collagen), and stem cell culture medium treatment group were measured.

• Proliferation effect
  on dermal fibroblast

  Considerable multiplication of fibroblas was identified according to the concentration of stem cell culture medium when Cellonic Booster was processed on dermal fibroblast.

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• Strengthening effect on skin barrier

  Keratinocyte differentiation marker was investigated to see if Cellonic Booster protects skin barrier from skin damage and improves skin troubles, and showed a significant increase in stem cell culture medium treatment group for TGN-2. According to the result of observing cell morphology, proliferation of Keratinocyte as well as intercellular adhesion increased significantly in stem cell culture medium treatment group, and Cellonic Booster is expected to strengthen skin barrier in skin troubles as atopic or psoriatic skin.

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• Whitening effect
  (inhibitory effect on melanogenesis)

  Whitening effect test of Cellonic Booster used B16F10 melanoma cell that produces melanin on the skin, stimulated melanin synthesis by force by adding melanocyte stimulating hormone(α-MSH) on melanoma cell, and processed albutin, a whitening material, and stem cell culture medium by concentration. As a result, it was identified that melanogenesis and whitening activity of stem cell culture medium are superior than albutin.

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• Whitening effect
  (Inhibitory effect on melanogenesis and tyrosinase)

  Melanin figure and tyrosinase enzyme activity, a core enzyme of melanin synthesis process, were measured to identify whitening function of stem cell culture medium, and melanin and tyrosinase suppressive activity of stem cell culture medium was identified to be more excellent than albutin.